Dr Amitha Hewavitharana

Amitha Hewavitharana

Research Fellow

E:  amitha.hewavitharana@scu.edu.au

Education:

PhD in Analytical Chemistry, University of Alberta, Canada
MSc in Chemistry, University of Victoria, Canada
BSc in Biology and Chemistry, University of Colombo, Sri Lanka

Research Gate: https://www.researchgate.net/profile/Amitha_Hewavitharana

ORCiD

Research interests/background

After completion of postgraduate studies in Canada, I moved to New Zealand and held brief research positions at Massey University (New Zealand) and NZ Leather Research Institute. Following that, I worked as a research scientist at the NZ Dairy Research Institute (NZDRI, currently Fonterra Research) for 4 years before moving to Australia in 1997.

In Australia, I commenced my career as a lecturer in analytical chemistry at the University of Western Sydney, and then at Queensland University of Technology (QUT) until 2001. Following that, I held research positions in CSIRO (food science), in QHSS (investigative chemistry), then in school of pharmacy at the University of Queensland (2014 – 2018).

Stemming from my PhD in analytical chemistry, my research is focused on solving fundamental analytical problems as well as developing analytical methods for a variety of applications such as: metal speciation (free/ionized calcium, and magnesium) and metabolite analysis (eg. pseudouridine, paracetamols, endorphins, dynorphins) in biological fluids, water, and waste water; nutrients (eg. vitamins), antinutrients (eg. lysiniolanine) and antioxidants (eg. carotenes, tocopherols, tocotrienols) in dairy foods and meat products; nutraceuticals in tropical fruits (eg. carotenes, quercetins, mangiferin, anticancer compounds); psychoactive compounds (THC); marker compounds such as isoprostanes, sinistrin, fluconazole, pindolol, p-amino hippuric acid and creatinine; drug discovery (antibiotics and anti-cancer compounds from marine sponge bacteria and tropical fruit); drug delivery (dendrimers) and drug assay (BAY-11-7082, paracetamol, endorphin); disease markers (eg. Sarcosine in prostate cancer); fat- and Water-soluble analogues of vitamin D; trace metals in food; ion suppression effects in mass spectrometry, and challenges in method validation. My research outcomes were achieved using a wide variety of instrumentation such as HPLC -MS-MS, -PDA, -fluorescence, -EC, etc, IC, GC-MS, HPCE, AAS, NIR, FTIR, FIA. My interests also include method validation and laboratory quality assurance in line with ISO 17025. I serve as a volunteer technical assessor to NATA and IANZ, in ISO accreditation of routine testing laboratories in Australia and New Zealand. 

Recent Awards

  • Developing a method for measuring thiopurine drug and metabolites (2018) Research Donation Generic
  • Analytical instrumentation enabling rapid compound separation and chemical structure analysis via mass fingerprinting (2010) UQ Major Equipment and Infrastructure

Recent Publications

Refereed Journal Articles

  • H.M.H.N. Bandara, A.K. Hewavitharana, P.N. Shaw, H.D.C. Smyth, L.P. Samaranayake (2020) A novel, quorum sensor-infused liposomal drug delivery system suppresses Candida albicans biofilms (2020). International Journal of Pharmaceutics 578, doi:10.1016/j.ijpharm.2020.119096
  • Pandey, Saurabh, Walpole, Carina, Shaw, Paul N., Cabot, Peter J., Hewavitharana, Amitha K. and Batra, Jyotsna Bio-Guided Fractionation of Papaya Leaf Juice for Delineating the Components Responsible for the Selective Anti-proliferative Effects on Prostate Cancer Cells (2018). Frontiers in Pharmacology, 9 NOV: 1319. doi:10.3389/fphar.2018.01319
  • Hewavitharana, Amitha K., Narayan, Vicrant and Duley, John A. (2018) Separation of highly charged compounds using competing ions with hydrophilic interaction liquid chromatography - application to assay of cellular nucleotides. Journal of Chromatography A, 1567 233-238. doi:10.1016/j.chroma.2018.07.006
  • Hewavitharana, Amitha K., Abu Kassim, Nur Sofiah and Shaw, Paul Nicholas (2018) Standard addition with internal standardisation as an alternative to using stable isotope labelled internal standards to correct for matrix effects-Comparison and validation using liquid chromatography-​tandem mass spectrometric assay of vitamin D. Journal of Chromatography A, 1553 101-107. doi:10.1016/j.chroma.2018.04.026
  • Abu Kassim, Nur Sofiah, Shaw, Paul Nicholas and Hewavitharana, Amitha K. (2017) Simultaneous determination of 12 vitamin D compounds in human serum using online sample preparation and liquid chromatography-tandem mass spectrometry. Journal of Chromatography A, 1533 57-65. doi:10.1016/j.chroma.2017.12.012
  • Pandey, Saurabh, Walpole, Carina, Cabot, Peter J., Shaw, Paul N., Batra, Jyotsna and Hewavitharana, Amitha K. (2017) Selective anti-proliferative activities of Carica papaya leaf juice extracts against prostate cancer. Biomedicine & Pharmacotherapy, 89 515-523. doi:10.1016/j.biopha.2017.02.050
  • Morgan, M., Heffernan, A., Benhabib, F., Wagner, S., Hewavitharana, A. K., Shaw, P. N. and Cabot, P. J. (2017) The efficacy of Dynorphin fragments at the κ, μ and δ opioid receptor in transfected HEK cells and in an animal model of unilateral peripheral inflammation. Peptides, 89 9-16. doi:10.1016/j.peptides.2016.12.019
  • Bose, Utpal, Ortori, Catharine A., Sarmad, Sarir , Barrett, David A., Hewavitharana, Amitha K. , Hodson, Mark P., Fuerst, John A. and Shaw, P. Nicholas (2017) Production of N-acyl homoserine lactones by the sponge-associated marine actinobacteria Salinispora arenicola and Salinispora pacifica. FEMS Microbiology Letters, 364 2: . doi:10.1093/femsle/fnx002
  • Gomes, Fabio, Shaw, Nick, Whitfield, Karen, Koorts, Pieter, McConachy, Helen and Hewavitharana, Amitha (2016) Effect of pasteurisation on the concentrations of vitamin D compounds in donor breast milk. Archives of disease in childhood, 101 9: e2. doi:10.1136/archdischild-2016-311535.26
  • Taufek, Nor Mohd, Cartwright, David, Hewavitharana, Amitha, Koorts, Pieter, McConachy, Helen, Shaw, Nick, Whitfield, Karen and Davies, Mark (2016) To investigate the effect of the pasteurisation process on trace elements in donor breast milk. e ADC, 101 9: A13-A14. doi:10.1136/archdischild-2016-311535.27
  • Pandey, Saurabh, Cabot, Peter J., Shaw, P. Nicholas and Hewavitharana, Amitha K. (2016) Anti-inflammatory and immunomodulatory properties of Carica papaya. Journal of Immunotoxicology, 13 4: 590-602. doi:10.3109/1547691X.2016.1149528
  • Mohd-Taufek, N., Cartwright, D., Davies, M., Hewavitharana, A. K., Koorts, P., McConachy, H., Shaw, P. N., Sumner, R. and Whitfield, K. (2016) The effect of pasteurization on trace elements in donor breast milk. Journal of Perinatology, 36 10: 897-900. doi:10.1038/jp.2016.88
  • Abu Kassim, Nur Sofiah, Gomes, Fabio P., Shaw, Paul Nicholas and Hewavitharana, Amitha K. (2016) Simultaneous quantitative analysis of nine vitamin D compounds in human blood using LC-MS/MS. Bioanalysis, 8 5: 397-411. doi:10.4155/bio.15.260
  • Nguyen, Thao T., Parat, Marie-Odile, Shaw, Paul N., Hewavitharana, Amitha K. and Hodson, Mark P. (2016) Traditional aboriginal preparation alters the chemical profile of carica papaya leaves and impacts on cytotoxicity towards human squamous cell carcinoma. PLoS ONE, 11 2: e0147956. doi:10.1371/journal.pone.0147956
  • Gomes, Fabio P., Shaw, P. Nicholas, Whitfield, Karen, Koorts, Pieter, McConachy, Helen and Hewavitharana, Amitha K. (2016) Effect of pasteurisation on the concentrations of vitamin D compounds in donor breastmilk. International Journal of Food Sciences and Nutrition, 67 1: 16-19. doi:10.3109/09637486.2015.1126566
  • Gomes, Fabio P., Shaw, P. Nicholas and Hewavitharana, Amitha K. (2016) Determination of four sulfated vitamin D compounds in human biological fluids by liquid chromatography-tandem mass spectrometry. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1009-1010 80-86. doi:10.1016/j.jchromb.2015.12.014
  • Mohd-Taufek, Nor, Cartwright, David, Davies, Mark, Hewavitharana, Amitha K., Koorts, Pieter, Shaw, Paul N., Sumner, Ronald, Lee, Eugene and Whitfield, Karen (2016) The simultaneous analysis of eight essential trace elements in human milk by ICP-MS. Food Analytical Methods, 9 7: 1-8. doi:10.1007/s12161-015-0396-z
  • Nguyen, Thao T., Parat, Marie-Odile, Hodson, Mark P., Pan, Jenny, Shaw, Paul N. and Hewavitharana, Amitha K. (2016) Chemical characterization and in vitro cytotoxicity on squamous cell carcinoma cells of Carica papaya leaf extracts. Toxins, 8 1: 7.1-7.11. doi:10.3390/toxins8010007
  • Al-Shehri, Saad S., Knox, Christine L., Liley, Helen G., Cowley, David M., Wright, John R., Henman, Michael G., Hewavitharana, Amitha K., Charles, Bruce G., Shaw, Paul N., Sweeney, Emma L. and Duley, John A. (2015) Breastmilk-saliva interactions boost innate immunity by regulating the oral microbiome in early infancy. PLoS One, 10 9: e0135047.1-e0135047.19. doi:10.1371/journal.pone.0135047
  • Bose, Utpal, Hewavitharana, Amitha K., Ng, Yi Kai, Shaw, Paul Nicholas, Fuerst, John A. and Hodson, Mark P. (2015) LC-MS-Based Metabolomics Study of Marine Bacterial Secondary Metabolite and Antibiotic Production in Salinispora arenicola.. Marine Drugs, 13 1: 249-266. doi:10.3390/md13010249
  • Pandey, Saurabh, Shaw, Paul N. and Hewavitharana, Amitha K. (2015) Review of procedures used for the extraction of anti-cancer compounds from tropical plants. Anti-Cancer Agents in Medicinal Chemistry, 15 3: 314-326. doi:10.2174/1871520614666141114202104
  • Gomes, Fabio P., Shaw, P. Nicholas, Whitfield, Karen and Hewavitharana, Amitha K. (2015) Simultaneous quantitative analysis of eight vitamin D analogues in milk using liquid chromatographyetandem mass spectrometry. Analytica Chimica Acta, 891 211-220. doi:10.1016/j.aca.2015.08.017
  • Ng, Y. K., Hodson, M. P., Hewavitharana, A. K., Bose, U., Shaw, P. N. and Fuerst, J. A. (2014) Effects of salinity on antibiotic production in sponge-derived Salinispora actinobacteria. Journal of Applied Microbiology, 117 1: 109-125. doi:10.1111/jam.12507
  • Bose, Utpal, Hewavitharana, Amitha K., Vidgen, Miranda E., Ng, Yi Kai, Shaw, Nicholas, Fuerst, John A. and Hodson, Mark P. (2014) Discovering the recondite secondary metabolome spectrum of Salinispora species: a study of inter-species diversity. PLoS One, 9 3: e91488.1-e91488.10. doi:10.1371/journal.pone.0091488
  • Bose, Utpal, Hodson, Mark P., Shaw, P. Nicholas, Fuerst, John A. and Hewavitharana, Amitha K. (2014) Bacterial production of the fungus-derived cholesterol-lowering agent mevinolin. Biomedical Chromatography, 28 9: 1163-1166. doi:10.1002/bmc.3138
  • Asvadi, Naghmeh Hajarol, Morgan, Michael, Herath, Herath M., Hewavitharana, Amitha K., Shaw, P. Nicholas and Cabot, Peter J. (2014) Beta-Endorphin 1-31 Biotransformation and cAMP Modulation in Inflammation. PLoS One, 9 3: e90380.1-e90380.11. doi:10.1371/journal.pone.0090380
  • Asvadi, Naghmeh H., Morgan, Michael, Hewavitharana, Amitha K., Shaw, P. Nicholas and Cabot, Peter J. (2014) Biotransformation of beta-endorphin and possible therapeutic implications. Frontiers in Pharmacology, 5 Article 18: 18. doi:10.3389/fphar.2014.00018
  • Hewavitharana, Amitha K., Darch, Katherine M. and Shaw, P. Nicholas (2014) Hydrophilic interaction liquid chromatography-tandem mass spectrometric determination of creatinine in human urine. Analytical Letters, 47 4: 689-696. doi:10.1080/00032719.2013.848363
  • Hewavitharana, Amitha K., Tan, Swee K. and Shaw, P. Nicholas (2014) Strategies for the detection and elimination of matrix effects in quantitative LC-MS analysis. LCGC North America, 32 1: 54-64.
  • Bose, Utpal, Hodson, Mark P., Shaw, P. Nicholas, Fuerst, John A. and Hewavitharana, Amitha K. (2014) Two peptides, Cycloaspeptide A and Nazumamide A from a sponge associated marine Actinobacterium Salinispora sp. Natural Product Communications, 9 4: 545-546.
  • Herath, H. M. D. R., Kim, R-R., Cabot, P. J., Shaw, P. N. and Hewavitharana, A. K. (2013) Inaccuracies in the quantification of peptides - A case study using beta-endorphin assay. LCGC Europe, 26 8: 435-437.
  • Hewavitharana, Amitha K., Tan, Zhi W., Shimada, Ryo, Shaw, Paul N. and Flanagan, Bernadine M. (2013) Between fruit variability of the bioactive compounds, β-carotene and mangiferin, in mango (Mangifera indica). Nutrition and Dietetics, 70 2: 158-163. doi:10.1111/1747-0080.12009
  • Hewavitharana, Amitha (2013) Current status of Vitamin D assays: are they reliable and sufficiently informative for clinical studies?. Bioanalysis, 5 11: 1325-1327. doi:10.4155/BIO.13.88
  • Nguyen, Thao T. T., Shaw, Paul N., Parat, Marie-Odile and Hewavitharana, Amitha K. (2013) Anticancer activity of Carica papaya: a review. Molecular Nutrition and Food Research, 57 1: 153-164. doi:10.1002/mnfr.201200388
  • Ng, Yi Kai, Hewavitharana, Amitha K., Webb, Richard, Shaw, P. Nicholas and Fuerst, John A. (2013) Developmental cycle and pharmaceutically relevant compounds of Salinospora actinbacteria isolated from Great Barrier Reef marine sponges. Applied Microbiology and Biotechnology, 97 7: 3097-3108. doi:10.1007/s00253-012-4479-0
  • Herath, H. M. D. R., Kim, R. -R., Cabot, P. J., Shaw, P. N. and Hewavitharana, A. K. (2013) Inaccuracies in the quantification of peptides - a case study using beta-endorphin assay. LCGC North America, 31 1: 58-61.
  • Gomes, Fabio P., Shaw, P. Nicholas, Whitfield, Karen, Koorts, Pieter and Hewavitharana, Amitha K. (2013) Recent trends in the determination of vitamin D. Bioanalysis, 5 24: 3063-3078. doi:10.4155/bio.13.283
  • Soliman, Laiel C., Hui, Yu, Hewavitharana, Amitha K. and Chen, David D. Y. (2012) Monitoring potential prostate cancer biomarkers in urine by capillary electrophoresis-tandem mass spectrometry. Journal of Chromatography A, 1267 7: 162-169. doi:10.1016/j.chroma.2012.07.021
  • Morgan, M., Herath, H. M. D. R., Cabot, P. J., Shaw, P. N. and Hewavitharana, A. K. (2012) Dynorphin A 1–17 biotransformation in inflamed tissue, serum and trypsin solution analysed by liquid chromatography–tandem mass spectrometry. Analytical and Bioanalytical Chemistry, 404 10: 3111-3121. doi:10.1007/s00216-012-6406-8
  • Dilanthi, H. M. D. R., Cabot, P. J., Shaw, P. N. and Hewavitharana, A. K. (2012) Study of beta endorphin metabolism in inflamed tissue, serum and trypsin solution by liquid chromatography-tandem mass spectrometric analysis. Analytical and Bioanalytical Chemistry, 402 6: 2089-2100. doi:10.1007/s00216-011-5686-8
  • Hewavitharana, Amitha K. (2011) Matrix matching in liquid chromatography-mass spectrometry with stable isotope labelled internal standards - Is it necessary?. Journal of Chromatography A, 1218 2: 359-361. doi:10.1016/j.chroma.2010.11.047
  • Wilkinson, Ashley, Flanagan, Bernadine M., Pierson, Jean-Thomas, Hewavitharana, Amitha, Dietzgen, Ralf G., Shaw, Paul N., Roberts-Thomson, Sarah J., Monteith, Gregory R. and Gidley, Mike (2011) Bioactivity of mango flesh and peel extracts on peroxisome proliferator-activated receptor gamma [PPARgamma] activation and MCF-7 cell proliferation: Fraction and fruit variability. Journal of Food Science, 76 1: 11-18. doi:10.1111/j.1750-3841.2010.01899.x
  • Hewavitharana, A. K., Herath, H. M. D. R., Shaw, P. N., Cabot, P. N. and Kebarle, P. (2010) Effect of solvent and electrospray mass spectrometer parameters on the charge state distribution of peptides - a case study using liquid chromatography/mass spectrometry method development for beta-endorphin assay. Rapid Communications in Mass Spectrometry, 24 24: 3510-3514. doi:10.1002/rcm.4806
  • Izumi, Hiroshi, Gauthier, Marie E.A., Degnan, Bernard M., Ng, Yi Kai, Hewavitharana, Amitha K., Shaw, P. Nicholas and Fuerst, John A. (2010) Diversity of Mycobacterium species from marine sponges and their sensitivity to antagonism by sponge-derived rifamycin-synthesizing actinobacteria in genus Salinispora. FEMS Microbiology Letters, 313 1: 33-40. doi:10.1111/j.1574-6968.2010.02118.x
  • Hewavitharana, Amitha (2010) Re: Florian Jentzmik, Carsten Stephan, Kurt Miller, et al. Sarcosine in Urine After Digital Rectal Examination Fails as a Marker in Prostate Cancer Detection and Identification of Aggressive Tumours. Eur Urol 2010;58:12-8. European Eurology, 58 4: E39-E40. doi:10.1016/j.eururo.2010.07.031
  • Herath, H. M. D. R., Shaw, Paul N., Cabot, Peter and Hewavitharana, Amitha (2010) Effect of ionization suppression by trace impurities in mobile phase water on the accuracy of quantification by high-performance liquid chromatography/mass spectrometry. Rapid Communications in Mass Spectrometry, 24 11: 1502-1506. doi:10.1002/rcm.4549
  • Daud, Noor Huda, Aung, Cho Sanda, Hewavitharana, Amitha K., Wilkinson, Ashley S., Pierson, Jean-Thomas, Roberts-Thomson, Sarah J., Shaw, P. Nicholas, Monteith, Gregory R., Gidley, Michael J. and Parat, Marie-Odile (2010) Mango extracts and the mango component mangiferin promote endothelial cell migration. Journal of Agricultural and Food Chemistry, 58 8: 5181-5186. doi:10.1021/jf100249s
  • Mutalik, S., Hewavitharana, A., Shaw, P. N., Anissimov, Y. G., Roberts, M. S. and Parekh, H. S. (2009) Development and validation of a reversed-phase high-performance liquid chromatographic method for quantification of peptide dendrimers in human skin permeation experiments. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 877 29: 3556-3562. doi:10.1016/j.jchromb.2009.08.039
  • Hewavitharana, Amitha (2009) Internal standard - friend or foe?. Critical Reviews in Analytical Chemistry, 39 4: 272-275. doi:10.1080/10408340903001201Hewavitharana, A., Shaw, P. N., Ng, Y. K. and Fuerst, J. A. (2009) Simple screening method for staurosporine in bacterial cultures using liquid chromatography-tandem mass spectrometry. Journal of Bioanalysis & Biomedicine, 1 1: 1-4. doi:10.4172/1948-593X.1000001
  • Hewavitharana, A., Lee, S., Dawson, P. A., Markovich, D. and Shaw, P. N. (2008) Development of an HPLC-MS/MS method for the selective determination of paracetamol metabolites in mouse urine. Analytical Biochemistry, 374 1: 106-111. doi:10.1016/j.ab.2007.11.011
  • Bruce, H. L., Hewavitharana, A. K. and Hunter, R. A. (2008) Creatinine and pseudouridine in plasma and urine from Braham-cross steers fed a low, medium or high plane of nutrition. Livestock Science, 119 1-3: 95-101. doi:10.1016/j.livsci.2008.03.006
  • Hewavitharana, A. K., Shaw, P. N., Kim, T. K. and Fuerst, J. A. (2007) Screening of rifamycin producing marine sponge bacteria by LC-MS-MS. Journal of Chromatography B-analytical Technologies In The Biomedical And Life Sciences, 852 1-2: 362-366. doi:10.1016/j.jchromb.2007.01.042
  • Pham, H. L., Ross, B. P., McGeary, R. P., Shaw, P. N., Hewavitharana, A. K. and Davies, N. M. (2006) Saponins from Quillaja saponaria Molina: Isolation, Characterization and Ability to Form Immuno Stimulatory Complexes (ISCOMs). Current Drug Delivery, 3 4: 389-397. doi:10.2174/156720106778559092
  • Lee, S., Dawson, P. A., Hewavitharana, A. K., Shaw, P. N. and Markovich, D. (2006) Disruption of NaS1 sulfate transport function in mice leads to enhanced acetaminophen-induced hepatotoxicity. Hepatology, 43 6: 1241-1247. doi:10.1002/hep.21207
  • Kim, T. K., Hewavitharana, A. K., Shaw, P. N. and Fuerst, J. A. (2006) Discovery of a new source of rifamycin antibiotics in marine sponge actinobacteria by phylogenetic prediction. Applied And Environmental Microbiology, 72 3: 2118-2125. doi:10.1128/AEM.72.3.2118-2125.2006
  • Hewavitharana, A. K., Hyde, C., Thomas, R. and Shaw, P. N. (2006) Shortcomings of protein removal prior to high performance liquid chromatographic analysis - A case study using method development for BAY 11-7082. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 834 1-2: 93-97. doi:10.1016/j.jchromb.2006.02.037
  • Hewavitharana, AK and Shaw, PN (2005) Enhancing the ratio of molecular ions to non-covalent compounds in the electrospray interface of LC-MS in quantitative analysis. Analytical And Bioanalytical Chemistry, 382 4: 1055-1059. doi:10.1007/s00216-005-3236-y
  • Hewavitharana, A.K., Golding, G., Tempany, G., King, G. and Holling, N. (2005) Quantitative GG-MS analysis of Delta(9)-tetrahydrocannabinol in fiber hemp varieties. Journal of Analytical Toxicology, 29 4: 258-261. doi:10.1093/jat/29.4.258
  • Lanari, MC, Hewavitharana, AK, Becu, C and de Jong, S (2004) Effect of dietary tocopherols and tocotrienols on the antioxidant status and lipid stability of chicken. Meat Science, 68 2: 155-162. doi:10.1016/j.meatsci.2003.12.004
  • Hewavitharana, A. K., Lanari, M. C. and Becu, C. (2004) Simultaneous determination of Vitamin E homologs in chicken meat by liquid chromatography with fluorescence detection. Journal of Chromatography A, 1025 2: 313-317. doi:10.1016/j.chroma.2003.10.052
  • Hewavitharana, AK (2003) Simple solutions to problems encountered in quantitative analysis of tocopherols and tocotrienols using silica columns. Analytical Biochemistry, 313 2: 342-344. doi:10.1016/S0003-2697(02)00589-4
  • Hewavitharana, AK and Bruce, HL (2003) Simultaneous determination of creatinine and pseudouridine concentrations in bovine plasma by reversed-phase liquid chromatography with photodiode array detection. Journal of Chromatography B-analytical Technologies In The Biomedical And Life Sciences, 784 2: 275-281. doi:10.1016/S1570-0232(02)00799-7
  • Hewavitharana, A. K. and Bruce, H. L. (2003) Simultaneous liquid chromatographic determination of creatinine and pseudouridine in bovine urine and the effect of sample pH on the analysis. Journal of Agricultural And Food Chemistry, 51 17: 4861-4865. doi:10.1021/jf030095z
  • Hewavitharana, A. K. and Van Brakel, A. S. (1998) A rapid saponification procedure for the simultaneous HPLC determination of the natural levels of vitamins A, E and beta-carotene in milk. Milchwissenschaft-Milk Science International, 53 1: 11-15.
  • van Brakel, A. S., Matheson, A. R. and Hewavitharana, A. K. (1997) Chromatographic problems related to mobile phase degassing and fluorescence detection. Journal of Chromatographic Science, 35 11: 545-548. doi:10.1093/chromsci/35.11.545
  • Hewavitharana, A. K. and van Brakel, B. (1997) Fourier transform infrared spectrometric method for the rapid determination of casein in raw milk. Analyst, 122 7: 701-704. doi:10.1039/a700953d
  • Wilkinson, J. and Hewavitharana, A. K. (1997) Lysinoalanine determination in sodium caseinate using the LKB Alpha Plus Amino Acid Analyser. Milchwissenschaft-Milk Science International, 52 8: 423-427.
  • Hewavitharana, A. K. (1996) Method for the extraction of riboflavin for high-performance liquid chromatography and application to casein. Analyst, 121 11: 1671-1676. doi:10.1039/an9962101671
  • Hewavitharana, A. K., van Brakel, A. S. and Harnett, M. (1996) Simultaneous liquid chromatographic determination of vitamins A, E and beta-carotene in common dairy foods. International Dairy Journal, 6 6: 613-624. doi:10.1016/0958-6946(95)00057-7
  • Hewavitharana, A. K. (1993) A Fast and Efficient Hplc Method for the Separation of Chromium Complexes in Chrome Tanning Solutions. Journal of the Society of Leather Technologists and Chemists, 77 5: 143-146.
  • Hewavitharana, A. K. and Kratochvil, B. (1993) An Ion-Exchange Atomic-Absorption Method for the Measurement of Ionized Calcium and Magnesium At Micromolar Concentrations. Canadian Journal of Chemistry-Revue Canadienne De Chimie, 71 1: 17-20. doi:10.1139/v93-002
  • Hewavitharana, A. K., Mutucumarana, V. and Kratochvil, B. (1991) An Ion-Exchange Atomic-Absorption Method for the Determination of Ionized Calcium At Millimolar Levels. Canadian Journal of Chemistry-Revue Canadienne De Chimie, 69 12: 1976-1979. doi:10.1139/v91-284
  • Kirk, A. D. and Hewavitharana, A. K. (1988) Reversed-Phase Chromatographic-Separation of Highly Charged Inorganic Cations and Anions Using Ion Interaction Reagents and Competing Ions. Analytical Chemistry, 60 8: 797-801. doi:10.1021/ac00159a013 

Conference Proceedings

  • Pandey, Saurabh, Walpole, Carina, Cabot, Peter J., Shaw, Paul N., Batra, Jyotsna and Hewavitharana, Amitha K. (2016). Medium polarity fraction of papaya leaf juice has selective antiproliferative effects on prostate cancer cells. In: 17th Asia-Pacific Prostate Cancer Conference, Melbourne, Australia, (24-24). Aug 31-Sep 03, 2016. doi:10.1111/bju.13567
  • Walpole, Carina, Pandey, Saurabh, Cabot, Peter J., Shaw, Paul N., Batra, Jyotsna and Hewavitharana, Amitha K. (2015). Carica papaya leaf juice extracts have selective anti-proliferative responses in prostatic disease. In: Abstracts of the 2nd Prostate Cancer World Congress, Australia. 2nd Prostate Cancer World Congress (PCWC), Cairns, QLD Australia, (44-44). 17-21 August 2015. doi:10.1111/bju.13198
  • Nguyen, Thao, Parat, Marie-Odile, Hodson, Mark P., Shaw, P. Nicholas and Hewavitharana, Amitha K. (2014). Investigation of compounds with cytotoxic activity in Carica papaya leaves. In: 6th International Conference on Drug Discovery & Therapy: Abstracts. ICDDT 2014: 6th International Conference on Drug Discovery and Therapy, Dubai, United Arab Emirates, (126-126). February 2014.
  • Asvadi, Naghmeh Hajarol, Morgan, Michael, Hewavitharana, Amitha, Shaw, P. Nicholas and Cabot, Peter J. (2013). Biotransformation within inflamed tissue of beta-endorphin 1-31 and three major N-terminal fragments; beta-endorphin 1-17, beta-endorphin 1-13, and beta-endorphin 1-11. In: 40th International Symposium on High Performance Liquid Phase Separations and Related Techniques: Delegate Handbook. HPLC 2013: 40th International Symposium on High Performance Liquid Phase Separations and Related Techniques, Hobart, TAS, Australia, (115-115). 18-21 November, 2013.
  • Bose, Utpal, Hodson, Mark, Vidgen, M., Shaw, N., Fuerst, J. and Hewavitharana, A. (2013). Chemical diversity of marine bacteria Salinispora arenicola and "Salinispora pacifica" associated with the host sponges Dercitus xanthus and Cinahyrella australiensis. In: Abstracts: Ninth World Sponge Conference 2013. Abstracts for Oral, Speed Talk and Poster Presentations. The 9th International Sponge Conference, Fremantle, WA, Australia, (11-11). 2013.
  • Bose, Utpal, Hodson, Mark P., Shaw, P. Nicholas, Fuerst, John A. and Hewavitharana, Amitha K. (2013). Discovering the hidden secondary metabolome of Salinispora arenicola: a study of intra-specific diversity. In: A. L. IL’ichev, R. T. Cardé, D. G. Williams and M. P. Zalucki, International Chemical Ecology Conference 2013: Program and Abstracts. ICEC 2013: International Chemical Ecology Conference, Melbourne, VIC, Australia, (). 19-23 August, 2013.
  • Bose, Utpal, Hodson, Mark P., Shaw, P. Nicholas, Fuerst, John A. and Hewavitharana, Amitha K. (2013). Intraspecific variability in secondary metabolites of the Great Barrier Reef sponge-associated marine bacteria "Salinispora pacifica". In: International Marine Biotechnology Conference, 10th Triennial Conference: IMBC 2013. Program and Abstract Handbook. IMBC 2013: 10th International Marine Biotechnology Conference, South Bank, QLD, Australia, (70-70). 11-15 November, 2013.
  • Bose, U., Hewavitharana, A. K., Vidgen, M. E., Shaw, P. N., Fuerst, J. A. and Hodson, M. P. (2013). Liquid chromatography-mass spectrometry metabolomic profiling to explore inter-species diversity in the genus Salinispora. In: FEMS 2013: 5th Congress of European Microbiologists, Leipzig, Germany, (). 21-25 July, 2013.
  • Bose, Utpal, Hodson, Mark P., Vidgen, Miranda E., Shaw, P. Nicholas, Fuerst, John A. and Hewavitharana, Amitha K. (2013). Patterns of chemical diversity on sponge associated marine bacteria. In: 9th Annual Conference of the Metabolomics Society: Full Abstracts. 9th Annual Conference of the Metabolomics Society, Glasgow, Scotland, U.K., (264-264). 1-4 July, 2013.
  • Morgan, Michael, Holgate, Jan, Hewavitharana, Amitha K., Shaw, Nick, Cabot, Peter and Bartlett, Selena E. (2013). The biotransformation of beta-endorphin in the rat brain after a single sedating dose of ethanol. In: Abstracts of the Australasian Professional Society on Alcohol and other Drugs Conference 2013. Australasian Professional Society on Alcohol and other Drugs Conference, Brisbane, QLD, Australia, (52-52). 24-27 November 2013. doi:10.1111/dar.12077
  • Hewavitharana, Amitha K. (2012). Dependence of secondary metabolite profiles of Salinispora species on their geographical distribution. In: 16th International Congress (PHYTOPHARM 2012), St Petersburg, Russia, (). 9-11 July 2012.
  • Bose, Utpal, Vidgen, Miranda, Shaw, Nick, Fuerst, John A. and Hewavitharana, Amitha (2011). Application of HPLC_QTOF-MS/MS to assess the chemical diversity of the marine actinobacterial genus Salinispora. In: Australian Pharmaceutical Science Association Conference, Adelaide, Australia, (). 2011.
  • Ng,Yi Kai, Hewavitharana, Amitha, Shaw, Paul N., Webb, Richard, Hooper, John and Fuerst, John A. (2011). Developmental cycle and antibiotic production of Salinispora arenicola isolated from Great Barrier Reef Marine sponges. In: Society for General Microbiology Autumn Conference 2011. Society for General Microbiology Autumn Conference 2011, York, United Kingdom, (). 5-7 September 2011.
  • Bala, Neeraj, Aitken, Elizabeth A.B., Hewavitharana, Amitha, Ross, Benjamin and Steadman, Kathryn (2011). Identification of antimicrobial compounds in the crude extracts of the Australian macrofungi, Hohenbuehelia sp. and Ramaria sp., through bioassay-guided fractionation. In: Australian Pharmaceutical Science Association Conference, Adelaide, Australia, (). 11-14 December 2011.
  • Herath, Dilanthi, Hewavitharana, Amitha K., Cabot, Peter J. and Shaw, P. Nicholas (2011). Identification of enzyme-sensitive cleavage sites of beta endorphin (beta- END) using serum and inflamed tissue. In: 22nd American Peptide Society Symposium. American Peptide Symposium (22nd, 2011), San Diego, CA, U.S.A., (509-509). 25-30 June 2011. doi:10.1002/bip.21670
  • Fuerst, John A., Hewavitharana, Amitha, Hooper, John, Izumi, Hiroshi, Ng, Yi Kai, Sagulenko, Evgeny, Shaw, Paul N., Schirra, Horst and Vidgen, Miranda (2011). Salinispora, Planctomycetes and their implications for sponge microbiology. In: 1st International sponge microbiology conf‏erence, Germany, (). 2011.